2016 Mercedes-Benz E350 Performance | Mercedes-Benz of Henderson The 2016 Mercedes-Benz E350 is a mid-size luxury sedan known for its comfortable ride, elegant design, and robust performance. It's powered by a 3.5-liter V6 engine producing 302 horsepower and comes with either rear-wheel drive or 4MATIC all-wheel drive. Key features include a 7-speed automatic transmission, a well-appointed interior with various technology and safety features, and a choice of trim levels with options like a sunroof, upgraded headlights, and leather seats.