The 2018 Ford F-250 Super Duty pickup slots between the light-duty Ford F-150 pickup and the Ford F-350 and F-450 Super Duty pickups in the automaker's truck lineup. With an all-new Ford F-Series Super Duty introduced in 2018, we don't expect any significant changes for the 2018 F-250 pickup. Changes to the 2018 Ford F-Series Super Duty include an all-new stronger frame, drivetrain bits, and towing hardware as well as a new aluminum-intensive cab and box.